All-new geek quotes, modified to celebrate the new forum - (Jan/26/2009 )
Bree Van De Kamp: Well, that's just too bad, because this needs to be discussed.
Desperate Housewives
well they're a plague, perhaps this also fits? 
Dr Forrester: I'm done talking. I'm all talked out. What's wrong with you, anyway?
Mystery Science Theatre 3000
oh yeaaah...and we shall inherit the earth... 
MacReady: I'm tired, Fuchs. I just wanna get up to my shack and get drunk.
The Thing
well start with your backyard, that's challenge enough for you and your pests
Roj Blake: Space fatigue, is that what they're saying?
Blakes 7
so why am I now in league with your bugs? it's all your fault as usual...
Michael Scott: Seasonal Affective Disorder - a depression that includes weight gain, fatigue, irritability brought on by the low light of winter.
The Office
seems so, but it was your idea, you're like the sorcerer's apprentice losing control
Adele Webber: You've had counseling?
Grey's Anatomy
well, I might consider the use of a nuclear device once and for all....
Lt. Cmdr. Data: Fortunately, none of my bio-functions seem affected. Do not be concerned, Counselor.
Star Trek: TNG
a dirty bomb in your apartment? well I guess you'll suffer more...except you wear protective lead clothes then all the time
Vincent Valentine: ...it's a symptom of alien matter infesting the body. When it tries to eliminate it, it overcompensates.
Final Fantasy VII: Advent Children
you want to live in your private Nagasaki? good luck
Special Agent Anthony Dinozzo: It's my metabolism. It's slowing with age. It's nothing a post holiday cleanse won't cure.
NCIS
but you're the big fan of dystopias here...
....