What is a prenylated protein? - (Sep/01/2005 )
I have a really dumb question ... what is a prenylated protein??? 
I can't get a definition on any on-line dictionary.
Thanks,
AussieUSA.
-AussieUSA-
wikipedia to the rescue!
Prenylation or isoprenylation is the addition of hydrophobic molecules to a protein to facilitate its attachment to the cell membrane. The result is similar to that of all lipid anchored proteins (e.g. the GPI anchor). All isoprenylation chains are products of the HMG-CoA reductase pathway: geranylgeraniol (GG), farnesol and dolichol.
http://en.wikipedia.org/wiki/Prenylation
hope that helps Aus...
-chempilot-
QUOTE (chempilot @ Sep 1 2005, 01:03 PM)
wikipedia to the rescue!
Prenylation or isoprenylation is the addition of hydrophobic molecules to a protein to facilitate its attachment to the cell membrane. The result is similar to that of all lipid anchored proteins (e.g. the GPI anchor). All isoprenylation chains are products of the HMG-CoA reductase pathway: geranylgeraniol (GG), farnesol and dolichol.
http://en.wikipedia.org/wiki/Prenylation
hope that helps Aus...
Prenylation or isoprenylation is the addition of hydrophobic molecules to a protein to facilitate its attachment to the cell membrane. The result is similar to that of all lipid anchored proteins (e.g. the GPI anchor). All isoprenylation chains are products of the HMG-CoA reductase pathway: geranylgeraniol (GG), farnesol and dolichol.
http://en.wikipedia.org/wiki/Prenylation
hope that helps Aus...
Thank You ChemPilot - you're a Star
-AussieUSA-