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2D electrophoresis of Plasma - (Jun/16/2005 )

2D gel on Plasma look like crap. Same way to run on other tissue look good. Anyone have any suggestion?

-faipoon-

Have you removed your albumin first by a column?
Have you run an small 1D to check how your sample runs in an SDS-page?
Do you use high quality reagents?
Do you filter all your buffers previous to use?

If you are more precise at the pattern you get,maybe I can help better.

M

-marcfe-

QUOTE (marcfe @ Jun 19 2005, 02:23 AM)
Have you removed your albumin first by a column?
Have you run an small 1D to check how your sample runs in an SDS-page?
Do you use high quality reagents?
Do you filter all your buffers previous to use?

If you are more precise at the pattern you get,maybe I can help better.

M

-faipoon-

Marc,
The problem is horizontal smearing? anyone have experience? see picutre? it suppose to glycoprotein> how can I make it look good?

-faipoon-