Regulation of protein may not be detected at RNA level - Can anyone tell me why??? (Nov/02/2005 )

Dear all,
Regulation of protein may not be detected at RNA level, can anyone tell me why? How often does this occur? This new knowledge makes me so curious
Thanks a lot.


Ribo

---

I would do a search for 'post-translational modification' at www.google.com to get all sorts of detailed info

---

regulation of post transcriptionnal events :
speed of translation
half life of mRNA

but also : glycosylation, phosphorylation (generally for activation/nactivation prot) prenylation sulfatation, add of other regulating groups...
regulation of a partner that be associated with your protein
ubiquitinylation of protein (leed to degradation by proteasmoe)

and this is the most commonly encountered.
There are many others...

---

Regulation of what? Expression (protein level) or activity? Protein level is a balance between expression ( corresponds to mRNA level) and specific and non-specific proteolysis. Difficult to say how often mRNA level does not correlate with protein concentration. As an example of the protein expression regulated by proteolytic degradation Cox2. Protein activity ia a different story.
Best wishes.
Mikki

---