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Silver stained 2-d gel BLOB!!! - (Apr/22/2010 )

Hi
I was wondering if someone could help me. Everytime I run my protein samples on 2-D gels and silver stain these gels I get this large blob at the base of the gel (see attached picture). I use GE IEF strips and ampholytes and Invitrogen pre-cast gels. I also use Invitrogen LDS sample buffer. I take great care not to touch the gels before staining.
Any help appreciated.
sam
Attached Image

-sam_boooko-

sam_boooko on Apr 22 2010, 11:31 PM said:

Hi
I was wondering if someone could help me. Everytime I run my protein samples on 2-D gels and silver stain these gels I get this large blob at the base of the gel (see attached picture). I use GE IEF strips and ampholytes and Invitrogen pre-cast gels. I also use Invitrogen LDS sample buffer. I take great care not to touch the gels before staining.
Any help appreciated.
sam



may be u shud try sum sample clean up kits available in the market!!

-Prep!-