Outlook for RNAi - will RNAi therapy go to bedside? - (Jun/28/2005 )

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Hi Guys,

RNAi is now so hot and we see great potential for it. Please share your views on the future of RNAi drug therapies.

-rajcell-

hi
regarding the difficulties to make a clinical assay with a "regular" medicament, siRNA therapy seems far away. For many reasons. But two of them are that at time there is no good vector to deliver RNAi and non wanted effects are quite important (interferon pathway activated by siRNA for example)...
So there is a big challenge to set up a vector and control effects before submitting a request for clinical assay....

But i'm hopful for these potentialities.
fred

-fred_33-

It is still too early to tell, but I am optimistic.

-pcrman-

Untill the specificity is accurate and off target silencing is contolled using RNAi in therapy could be bit risky. Imagine if I target RNAi against any general gene and because of mismatch, microRNA blocks the traslation of a tumor suppressor!!! But as still the field of RNAi is in infancy more research can help in reducing the drawbacks!

-Molonco-

QUOTE (fred_33 @ Jun 28 2005, 12:40 PM)

Just out of curiosity, do you happen to know the siRNA size limit to avoid triggering the interferon response? I thought it was >30bp, but I may be mistaken.

-Hank

-haringsh-

U r right. If the siRNA is more than >30bp it can lead to IF response. Anyway genearlly used siRNAs are around ~22bps.

-Molonco-

I have seen many papers using this technique. So, I think, it's so hot and so many lab are focus on it. It will have a very bright foregroud.

-superM2008-

Does anyone know who was the first person to mention the existence of silencing. I might be silly to ask such thing, but i do not know and i am really wondering.......

-solmaniar-

5 years according to me...

-bingo-

Indeed we are the RNAi in our experiments, but I do think there is still a long way to go to bedside.
pLiu

-huzzar-

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