Leucine-rich repeats - (Mar/04/2005 )

What is the significance of leucine-rich repeats? How much they affect the final product of protein?

hi
Leucine-rich repeats (LRRs) are 20-29-residue sequence motifs present in tandem arrays a number of proteins with diverse functions, such as hormone – receptor interactions, enzyme inhibition, cell adhesion and cellular trafficking.
The primary function of these motifs appears to be to provide a versatile structural framework for the formation of protein-protein interactions.


you can ave a look at this publications :

1. Kobe B. , Kajava A.V.
The leucine-rich repeat as a protein recognition motif.
Curr. Opin. Struct. Biol. 11: 725- 732 (2001)
http://www.ncbi.nlm.nih.gov/entrez/query.f...4&dopt=Abstract

2. Kajava A.V. , Kobe B.
Assessment of the ability to model proteins with leucine-rich repeats in light of the latest structural information.
Protein Sci. 11: 1082- 1090 (2002)
http://www.ncbi.nlm.nih.gov/entrez/query.f...5&dopt=Abstract

Fred

PS : summed up from http://www.ebi.ac.uk/interpro/IEntry?ac=IPR001611