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help with mechanism - (Nov/12/2008 )

Iam treating my cancer cells with a compound which causes the cells to round up and detach within 1hr after treatment . but the cells reattach later witihin 24hrs and grow even though the cell morphology is still distorted . Can someone can give any mechanistic insights on this. What are the proteins that i should be looking at ?

-missi-

What is the compound? What do you think might be some of the proteins involved? I would perhaps look at some of the stress response proteins.

-bob1-

QUOTE (missi @ Nov 12 2008, 09:35 AM)
Iam treating my cancer cells with a compound which causes the cells to round up and detach within 1hr after treatment . but the cells reattach later witihin 24hrs and grow even though the cell morphology is still distorted . Can someone can give any mechanistic insights on this. What are the proteins that i should be looking at ?


look for proteins of the focal adhesion site (integrins, FAK, c-Src, paxillin etc)

-The Bearer-