Codons particularly vunerable to mutation? - (Mar/21/2007 )

Hi,

my protein has a number of deleterious mutations associated with it, however, there is one codon in particular that has 2 reported mutations resulting in the generation of 2 separate amino acids.

I have heard of recombination hotspots, but I was wondering if there was such a case of mutation hotspots. I mean, it is interesting that this codon in particular has 2 eleterious mutations associated with it.

Any literature references or ideas to bounce around would be appreciated?

cheers

There would be a particular likelihood of that happening by chance.

The fact that one codon can make a variety of different amino acids with only a single nucleotide change means it has to code for its amino acid with very little wobble. Trp and Met are "single codon" amino acids, and there's a raft of other that are coded by only two codons. What amino acid is the one that you are seeing mutated?