Synonymous/nonsynonymous susbstitution - (Jan/16/2007 )
Hi people,
I have been reading a few things about synonymous and non-synoymous substitutions in nucleic acids and as to what their rates of substitutions might mean....but there are few things which i could not understand like
1. what does saturation of Synoymous/non synonymous substitution means ?. In what scenarios is such an observation made ?
2. How can one test for saturation of susbstitution.....i mean how does one know saturation has occurred ?
3. I understand that there are many caveats in estimation of these rates like sequence alignment, and how evolutionarily close the sequences are.....Is there any good review which describes as to how i can overcome these problems ?
have a good day!!!.
I have been reading a few things about synonymous and non-synoymous substitutions in nucleic acids and as to what their rates of substitutions might mean....but there are few things which i could not understand like
1. what does saturation of Synoymous/non synonymous substitution means ?. In what scenarios is such an observation made ?
2. How can one test for saturation of susbstitution.....i mean how does one know saturation has occurred ?
3. I understand that there are many caveats in estimation of these rates like sequence alignment, and how evolutionarily close the sequences are.....Is there any good review which describes as to how i can overcome these problems ?
have a good day!!!.
If you could overcome these problems then I think you would really achieve something special. As far as I am aware such problems are non-trivial and continue to cause divides in the evolutionary field.
I suggest looking at papers by:
Goldman N
Zhang Z
Goldstein R
Hein J
Thanks perl munky....
I will be glad if you have any more inputs on what saturation of substitutions might mean ? and how to test for them ?
have a good day!!