NFKappaB inhibitor - NFKB inhibitor (Nov/10/2006 )

Hi, I m looking for a specific NFKB inhibitor. Can you help me to find it? I already used PDTC but il is not spécific!! Thank you.

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have a look at this paper :
May et al 2000, Science 289 : 1550-1554.
selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkapB kinase complex.

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6-Amino-4-(4-phenoxyphenylethylamino)quinazoline blocks NFkappa B in the nm range; relative cheap

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Thank you very much I will tested NBD peptide

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Bay 11-7082 also works... not sure how though.

V

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NF-kappa B is a central key of several signal pathways. Many compounds will inhibit it, but how specifically?
If you want to publish a good paper, you need to know how it inhibits, and how selective it is.

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Thank you for your reply,

i think NBD peptide and 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline are more slective than Bay 11-7082 because i think Bay may interfere with other pathaways Independently of NFKappaB

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