exciting enzyme - (Jun/21/2006 )

Can any body tell me whats the most active area regarding enzme structure function and membrane protein from neuroscience point of view, in neurodegenerative disease.
I would like to read and work on that.
Your suggestion is ever appreciated.
regards
samita

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There r too many enzymes and proteins to point out one or other.

So u want some thing which is related to neurodegenerative diseases.

Second most common neurodegenerative disease is parkinsons (which is where I am interested in).

In parkinsons, there r a couple of new proteins adding to the genetic component of PD. Like Pink1, Parkin, a-synuclein, DJ-1, LRRK2 etc.

Of course, the top one is Alzheimer's.

u could look at some reviews for these diseases and start from there.

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As an alternative to studying a specific protein in neurodegenerative disease, why not look at amyloidogenesis? I was told once that any protein can be forced into making amyloid, and the speaker wasn't exaggerating. Seeing as how many neurodegenerative diseases are looking like they're caused by, or cause, amyloid generation and pathology, you should have plenty of options...

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BACE1 (beta-secretase) is a big one in alzheimer's.

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I thought the most exciting enzyme is where there is most of fire burning there. -A junior's answer.

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