cre recombinase - in cell lines (Nov/27/2005 )

Does anyone know if disruption of genes or 'promoter of a gene' done by Cre-recombinase experiments can be done in cell culture or cell lines ...please let me know os a paper if anyone here knows

thanks

hi there
try this

http://www3.interscience.wiley.com/cgi-bin...001850/PDFSTART

I work with cre/lox system in plants.
I'm sure that it's already been used in mammalian cells (CHO cells), but in this moment I can't find the reference...