PMA vs m-CSF - Does anybody knows? (Nov/05/2005 )

Dear all:

Do you know what is the difference in terms of the mechanisms of activation of monocytes by PMA or mCSF?
Thanks!

PMA: "Phorbol esters are functional analogs of diacylglycerol (DAG) that have been used to stimulate MAPK signaling via insulin-independent pathways."

M-CSF: described in:

"Transcriptional program of mouse osteoclast differentiation governed by the macrophage colony-stimulating factor and the ligand for the receptor activator of NFkappa B."
J Biol Chem. 2002 Jun 14;277(24):21971-82. Epub 2002 Mar 28.

mike