Sox2 and neuron differentiation - what's the reuslt if Sox2 is suppressed (Feb/10/2009 )
Dose any one know if Sox2 is "turn off" in the neural stem cell, will the stem cell differentiate into cells other than neurons?
Thank you!
This is as close as I could get:
Rogers CD, Harafuji N, Cunningham DD, Archer T, Casey ES. Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives. Mech Dev. 2008 Oct 17.
http://www.ncbi.nlm.nih.gov/pubmed/18992330
And here's some more recent data on regulation of sox2:
Feijóo CG, Saldias MP, De la Paz JF, Gómez-Skarmeta JL, Allende ML. Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Mol Cell Neurosci. 2008 Dec 6.
The straightforward approach might be to knock down Sox2 in neural stem cells and see how they differentiate.
Thanks, Jon!
Jon Moulton on Feb 25 2009, 09:27 AM said:
Rogers CD, Harafuji N, Cunningham DD, Archer T, Casey ES. Xenopus Sox3 activates sox2 and geminin and indirectly represses Xvent2 expression to induce neural progenitor formation at the expense of non-neural ectodermal derivatives. Mech Dev. 2008 Oct 17.
http://www.ncbi.nlm.nih.gov/pubmed/18992330
And here's some more recent data on regulation of sox2:
Feijóo CG, Saldias MP, De la Paz JF, Gómez-Skarmeta JL, Allende ML. Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Mol Cell Neurosci. 2008 Dec 6.
The straightforward approach might be to knock down Sox2 in neural stem cells and see how they differentiate.