Protocol Online logo
Top : New Forum Archives (2009-): : Molecular Biology

minor risk allele - (May/31/2020 )

Hi, Im new to GWAS studies and would appreciate any help in understanding risk alleles associated with diseases.

 

kindly refer to the attached figure

 

In the above table for PNPLA3: G is the risk allele. GC and GG genotypes were significantly associated with increased risk of NAFLD. Is this because more samples with NAFLD have G allele compared to healthy samples and this difference is significant?

 

Also, is the risk higher (more significant) with GG than with GC genotype for NAFLD?

 

Thank you

-SF_HK-

The above is referring to table 2 from this link:  https://www.frontiersin.org/files/Articles/211420/fgene-07-00140-HTML/image_m/fgene-07-00140-t002.jpg

 

From ref: Wang X, Liu Z, Wang K, Wang Z, Sun X, Zhong L, Deng G, Song G, Sun B, Peng Z and Liu W (2016) Additive Effects of the Risk Alleles of PNPLA3 and TM6SF2 on Non-alcoholic Fatty Liver Disease (NAFLD) in a Chinese Population. Front. Genet. 7:140. doi: 10.3389/fgene.2016.00140

-SF_HK-