Can microglia stain positive for phagocytosed material? - (May/30/2016 )

Hello Bioforumers,

Does anyone know if it is possible for microglia to become immunoreactive for antigens that they have phagocytosed? I performed xenotransplantation of human cells into mouse brains and found some microglia to be positive for human-specific antigens. 

Thanks in advance  .

~neuropath~

Well, microglia are APCs, so I would expect them to partially digest and present on the surface everything they encounter. 

Trof on Thu Jun 2 19:39:03 2016 said:

Well, microglia are APCs, so I would expect them to partially digest and present on the surface everything they encounter. 

Thanks for your reply Trof.