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Fatty Acid Synthesis - (Jul/28/2014 )

I looked up fatty acid synthesis and it says that for saturated fatty acid formation that 6 steps happen with 2 carbon acetyl CoA molecules until palmatic acid which is a 16 carbon fatty acid is formed.

 

Fatty acids are just carboxylic acids which naturally occur with 4 or more carbons but can have less than 4 carbons. How would all those other fatty acids by length be synthesized because surely 16C fatty acids are not the only ones synthesized.

-caters-

The synthesis, as you have read, is a cyclic process where the length is increased by two carbons every cycle. If the cycle stops early or goes on, either longer or shorter fatty acid chains are formed.

-phage434-

yeah but I have only read that palmitic acid which is a 16 carbon, straight chain, saturated fatty acid is what is formed during fatty acid synthesis.

 

Could it be that palmitic acid is the major product but other fatty acids form as well?

-caters-

Yes, and of course there are also modifications which produce unsaturated versions of these fatty acids.

-phage434-

and modifications for branched chain fatty acids. But then how do the odd numbered ones get formed like a 33C fatty acid for example if 2 carbons are added per cycle?

-caters-

Via Propionyl-CoA. You can find a lot of infos by googling odd number fatty acid synthesis, e.g. this one: http://www.cliffsnotes.com/sciences/biology/biochemistry-ii/fatty-acid-oxidation/odd-numbered-chain-and-branched-fatty-acids

-Tabaluga-