Bioinformatics characterization of proteins - Suggestions of tools (Oct/16/2010 )
Raviraj on Mon Jan 10 06:11:37 2011 said:
Dear all,
I am analyzing gene called ROCK1 ( accession no-NM 031098). I have to find out whether ROCK1 has any binding sites in the HES/HERP or any sites on Notch-1 (all the experiments have done on Rat). I have found the higher expression of ROCK1 down regulates the Notch1 or vise versa in protein and RNA level. To further investigate, I need to explain through finding of binding sites in Notch-1 or HES/HERP. I am quite new to the Bioinformatics field. Could anyone can help on this?
Thanks in advance,
Ravi
First I would try to find if there is a consensus binding site for ROCK1 (look in the literature). Then I would look for that motif in the two target proteins.
-cardosopedro-