looking for kinase inhibitor to study phosphatase - kinase inhibitor (Inhibit phosphorylation on transmembrane receptor) (Sep/15/2010 )

Hey all,

Would like to find out is there any available kinase inhibitor(s) to inhibit phosphorylation on transmembrane receptor? Are they kinase dependent or is there a chemical which can do just a specific one?

Warmest regards,
UNO

UNO on Wed Sep 15 10:19:27 2010 said:

There are many different kinase inhibitors available. Some inhibit specific kinases, some inhibit classes of kinases and some inhibit a wide variety. Do you have a specific kinase in mind that you want to inhibit? For example, I use roscovitine to inhibit the cyclin-dependent kinases.

UNO on Wed Sep 15 10:19:27 2010 said:

receptor tyrosine kinases are both cis- and transphosphorylated whereas G-protein coupled receptors are only cisphosphorylted; you have to choose the right inhibitor to block the phosphorylation of a specific site...

Kinase inhibitors can specifically block the activity of one or more protein kinases.

Sigma aldrich has several application notes on kinase inhibitors which list many inhibitors and their targets