Spontaneous movements during perfusion ("formalin dance") - (Jun/26/2010 )
I've really tried to find out how this works, but neither anyone at my lab nor google seems to be able to give me an answer. :-) Hope you are!
What is the mechanism behind the spontaneous movements ("formalin dance") during fixation of e.g. mice or rats?
-Eleanore-
Eleanore on Jun 26 2010, 12:21 PM said:
I've really tried to find out how this works, but neither anyone at my lab nor google seems to be able to give me an answer. :-) Hope you are!
What is the mechanism behind the spontaneous movements ("formalin dance") during fixation of e.g. mice or rats?
What is the mechanism behind the spontaneous movements ("formalin dance") during fixation of e.g. mice or rats?
Though I'm not a fixation or vertebrate expert I could imagine that this happens when body water is replaced by formalin and proteins and structures like tendons, fibres and filaments are denatured and change size and shape. This could lead to compensating motions. Also changes in osmotic pressure and strong diffusion flows (water out, formalin in) during this process may lead to such movements.
-hobglobin-