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assay for penicillinase - (Sep/09/2009 )

Hello everybody,
Does anyone know how to perform assay for penicillinase?. I ve heard of an assay with nitroefin, but this reagent is very expensive. I have read about spectrophotometric assays using a UV spectrophotometer.Pls help

-chn09-

chn09 on Sep 9 2009, 12:39 PM said:

Hello everybody,
Does anyone know how to perform assay for penicillinase?. I ve heard of an assay with nitroefin, but this reagent is very expensive. I have read about spectrophotometric assays using a UV spectrophotometer.Pls help

Have a look at these articles:

Yamabe S. Rapid spectrophotometric method for the determination of beta-lactamase activity. J Antimicrob Chemother. 1980;6:261-6.

Waley SG. A spectrophotometric assay of b-lactamase activity on penicillins. Biochem J. 1974;139:789-9.

Hope this helps

-klinmed-