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GOrilla - a tool for identifying enriched GO terms

GORILLA

Gene Ontology enRIchment anaLysis and visuaLizAtion tool

GOrilla is a tool for identifying and visualizing enriched GO terms in ranked lists of genes.
It can be run in one of two modes:

Searching for enriched GO terms that appear densely at the top of a ranked list of genes or
Searching for enriched GO terms in a target list of genes compared to a background list of genes.

For further details see References.

Running example Usage instructions GOrilla News(Updated Feb 7th 2010) References

Step 1: Choose organism

Step 2: Choose running mode

Single ranked list of genes       Two unranked lists of genes (target and background lists)

Step 3: Paste a ranked list of gene/protein names
Names should be separated by an <ENTER>. The preferred format is gene symbol. Other supported formats are: gene and protein RefSeq, Uniprot, Unigene and Ensembl. Use WebGestalt for conversion from other identifier formats.

Target set:

Or upload a file:

Background set:

Or upload a file:

Step 4: Choose an ontology

Process       Function      Component    All New!

Advanced parameters

P-value threshold:

Output results in Microsoft Excel format

Output unresolved and duplicate genes

Run GOrilla in fast mode

References

If you choose to use this application please cite:

Eran Eden*, Roy Navon*, Israel Steinfeld, Doron Lipson and Zohar Yakhini. "GOrilla: A Tool For Discovery And Visualization of Enriched GO Terms in Ranked Gene Lists", BMC Bioinformatics 2009, 10:48.
Eran Eden, Doron Lipson, Sivan Yogev, Zohar Yakhini. "Discovering Motifs in Ranked Lists of DNA sequences", PLoS Computational Biology, 3(3):e39, 2007.

Graphics are generated using Graphviz.

Components of the GOrilla system were designed as part of the European Union FP6 funded Multi Knowledge Project.

http://www.multiknowledge.org/

Creating New Knowledge In Networks of Medical Research

Please send your comments, suggestions and bug reports to Roy Navon at:
For questions regarding your results, please include a link to your results page.