 |
BioProduct : Immunology : Antibodies : Secondary Antibodies : p21 Polyclonal Antibody
| Product Name | p21 Polyclonal Antibody |
| Product Page | Visit the Product |
| Product Description | "CDKN1A （cyclin dependent kinase inhibitor 1A)encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of CDKN1A is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack CDKN1A have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for CDKN1A." |
| Product Manual | Read Product Manual |
| Price | $360 |
| Specification | 200μl |
| Product Review | 0
 |
| Vendor Information |  Abbkine Scientific https://www.abbkine.com Bldg 1, Harbour of Technology Times, No.35, Optical Valley Ave Wuhan Hubei 430074 China Phone: +86-27-59716789 Fax: +86-27-59716788 E-Mail: service@abbkine.com |