BioProduct : Immunology : Antibodies : Secondary Antibodies : MARK1 : 2 : 3 : 4 (phospho Thr215) Polyclonal Antibody

Product Name	MARK1/2/3/4 (phospho Thr215) Polyclonal Antibody
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Product Description	"Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking . The MARK (MAP/microtubule affinity-regulating kinases) family (MARK1-4) of serine/threonine kinases was identified based on their ability to phosphorylate microtubule-associated proteins (MAPs) including tau, MAP2 and MAP4 . MARK proteins phosphorylate MAPs within their microtubule binding domains, causing dissociation of MAPs from microtubules and increased microtubule dynamics . In the case of tau, phosphorylation has been hypothesized to contribute to the formation of neurofibrillary tangles observed in Alzheimer's disease. Overexpression of MARK leads to hyperphosphorylation of MAPs, morphological changes and cell death . The tumor suppressor kinase LKB1 phosphorylates MARK and the closely related AMP-kinases within their T-loops, leading to increased activity ."
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Price	$100
Specification	30μl
Product Review	0
Vendor Information	Abbkine Scientific  https://www.abbkine.com Bldg 1, Harbour of Technology Times, No.35, Optical Valley Ave Wuhan Hubei 430074 China Phone: +86-27-59716789 Fax: +86-27-59716788 E-Mail: service@abbkine.com