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BioProduct : Chemicals & Compounds : AZD6244
| Product Name | AZD6244 |
| Product Page | Visit the Product |
| Product Description | Activating mutations in the BRAF gene, primarily at V600E, are associated with poorer outcomes in patients with papillary thyroid cancer. MAPK kinase (MEK), immediately downstream of BRAF, is a promising target for ras-raf-MEK-ERK pathway inhibition. In addition to thyroid cancer, BRAF-activating mutations are prevalent in melanoma (-59%), colorectal cancer (5¨C22%), serous ovarian cancer (-30%), and several other tumor types. Four lines bearing V600E BRAF mutations were all sensitive to AZD6244, with GI50 values ranging from 14 to 50 nM. A positive control BRAF mutant melanoma line, SKMel28, exhibited a similar GI50 of 23 nM. |
| Product Manual | Read Product Manual |
| Price | $160 |
| Specification | 5mg |
| Product Review | 0
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| Vendor Information |
Selleck
http://www.selleckchem.com/ 2626 South Loop West, Suite 225, Houston, TX 77054 USA TX USA |