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BioProduct : Immunology : Antibodies : Secondary Antibodies : AF-4 Polyclonal Antibody
| Product Name | AF-4 Polyclonal Antibody |
| Product Page | Visit the Product |
| Product Description | "AFF1 encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, AFF1has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants." |
| Product Manual | Read Product Manual |
| Price | $220 |
| Specification | 100μl |
| Product Review | 0
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| Vendor Information |  Abbkine Scientific https://www.abbkine.com Bldg 1, Harbour of Technology Times, No.35, Optical Valley Ave Wuhan Hubei 430074 China Phone: +86-27-59716789 Fax: +86-27-59716788 E-Mail: service@abbkine.com |