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BioProduct : Immunology : Antibodies : ATM Phospho (pS1981)
| Product Name | ATM Phospho (pS1981) |
| Product Page | Visit the Product |
| Product Description | ATM is a nuclear phosphoprotein involved in Ataxia-telangiectasia (A-T) an autosomal recessive disorder characterized by cerebellar ataxia, immune deficiencies, increased cancer predisposition, chromosomal instability and radiation sensitivity (1-2). This large protein (370 kDa) is involved in genome stability, cellular responses to DNA damage and cell cycle control. Autophosphorylation at serine 1981 on ATM is required during ATM kinase activation initiated by double strand breaks in the genome. After serine 1981 autophosphorylation, ATM phosphorylates downstream proteins (e.g. p53, Chk2), leading to cell cycle arrest and DNA repair (3). More than 100 mutations have been identified so far and are expected to inactivate the ATM protein by truncation or large deletions (4). Defects in ATM contribute to various B-cell and T-cell leukemias (5). |
| Product Manual | Read Product Manual |
| Price | $285.00 |
| Specification | 100ul |
| Product Review | 0
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| Vendor Information |  Epitomics https://www.epitomics.com/products/index.php 863 Mitten Road, Suite 103 Burlingame CA 94010 USA Phone: (877) 772-2622 Fax: (650) 583-6680 E-Mail: Rabmabs@epitomics.com |