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BioProduct : Immunology : Immunohistochemistry Reagents : MSH6
| Product Name | MSH6 |
| Product Page | Visit the Product |
| Product Description | The MutS homologue 6 protein (MSH6) is a member of the MutS homolog family required in the DNA mismatch repair system (1). MSH6 forms a MutS alpha dimer with MSH2, binding to DNA mismatches to initiate DNA repair (2). MutS alpha bends the DNA helix and recognizes single base mismatches and dinucleotide insertion-deletion loops in the DNA (2). Heterozygous mutations in the MSH6 gene are a cause of hereditary nonpolyposis colorectal cancer (HNPCC), forming a specific mispair binding complex with MSH3 (3, 4). The frequency of MSH6 mutation is higher in HNPCC than in atypical HNPCC (5). The MSH2/MSH6 dimer may also play a role in DNA homologous recombination repair (2). |
| Product Manual | Read Product Manual |
| Price | $250.00 |
| Specification | 100ul |
| Product Review | 0
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| Vendor Information |  Epitomics https://www.epitomics.com/products/index.php 863 Mitten Road, Suite 103 Burlingame CA 94010 USA Phone: (877) 772-2622 Fax: (650) 583-6680 E-Mail: Rabmabs@epitomics.com |