isoform - mimani (Dec/28/2004 )

hi all

do you know about the isoforms of one protein What is the isoform?
What is the origin of isoform?
mehdi

Isoforms are different splicings of the same gene. The protein I am looking at has 3 isoforms. For example in my protein: Isoform 2 includes exons 2, 3, and 6; and exons 3 and 6 use alternate splice sites, when compared to isoform 3. The encoded protein for isoform 2, has a unique N-terminus compared to the other isoforms since its coding sequence starts in exon 2; its C-terminus is also unique due to use of a different termination codon. Isoform 1 includes exons 4, 5, and 6; and exon 4 uses an alternate splice site, as compared to isoform 3. Isoform 1 encoded protein, has a unique N-terminus compared to the other isoforms since its coding sequence starts in exon 4; its C-terminus is identical to isoform 3.