Pharmacokinetics - please help! - (May/07/2008 )

Hi folks!

Please could you help a lowly undergrad...

What are the following kinetic parameters used for? More specifically, what do they mean and how are they determined?

I/IC50, I2/IC50

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I have no idea of the terms you are asking about. But in case if you are wondering about IC50, it is the concentration of drug/chemical that inhibits the targeted activity by 50%. There is also LD50 (50% of lethal dose for any organism or cells) and EC50 which is used in the same way as IC50, but more refers to agonist compound activity.

HTH/

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actually, LD50 is the dose that is lethal to 50% of the cells or organisms.

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IC50 is half maximum inhibitory concentration of a (small-molecular) inhibitor;

is the first I in I/IC50 meant as 1?

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