Does transcription factor affect mRNA half-life? - (Sep/05/2006 )
I am curious about this but not found information from the website. Anyone has some idea?
Thanks.......
Thanks.......
A transcription factor can increase or decrease the amount of a specific RNA. This is not the half-life of the RNA. I don't feel like excluding this possibility but this would imply that the TF can bind, relocalize, protect, make more accessible to RNases your RNA. Nothing is impossible...
Well a TF could affect RNA half-life but only in an indirect and tenuous manner.
Imagine a TF that causes increase mRNA production of an enzyme which increases mRNA stability. Conversely a TF might repress the transcription of RNases and related proteins.
good poits. thanks. 
Thanks.......
Ya.. i wud say TF wud protect it from RNAses by binding the RNA..
TF are binding the DNA and thus are not reponsible of the stability of the RNA per se.
The stability factor involved for in mRNA my be the PABP (poly A binding protein).
I'm remembering that a RNA of a 30' half life was stable for only 5' if lacking the poly A tail.
Then for translation, if the ribosome encounter difficulties, the mark protein is
see this link and this one which gives selected readings too, and a good ppt here
see also Lykke-Andersen Curr Biol. 2001 11(3):R88-91.
nice websites.
thanks a lot! 
The stability factor involved for in mRNA my be the PABP (poly A binding protein).
I'm remembering that a RNA of a 30' half life was stable for only 5' if lacking the poly A tail.
Then for translation, if the ribosome encounter difficulties, the mark protein is
see this link and this one which gives selected readings too, and a good ppt here
see also Lykke-Andersen Curr Biol. 2001 11(3):R88-91.
There is another mechanism for TF modulation of RNA half-life. Recently its been shown that miRNAs are transcriptionally regulated as any other transcript would be - through TF binding and recruitment of initiation complexes. Its only been described so far for c-myc and CREB if I recall, but this is another level of TF regulation of mRNA stability, albeit still an indirect one.