Holliday Model of Homologous Recombination VIDEO MISTAKE? - (Dec/02/2013 )
Hello,
In class today the teacher said there is something wrong with the following animation of the "Holliday Model of Homologous Recombination":
http://www.youtube.com/watch?v=bkoJOZCoOOg
She didn't say what it is but I will have to know this on the test very accurately and the video is very helpful, if it wouldn't be for this small mistake, for which I don't know where it is.
My question is, where in the video is this mistake. It would be much appreciated if someone who knows this subject could take a look at the whole video and point out the mistake.
Thank you,
Rok
I am not sure this might be the mistake, but it seems that when they draw the chromosomes
at 1.29 and at 1.49 (and I am talking about the "large chromosomes" on top, not the in detail view) that there is something wrong with the colors.
I mean these ones:
Look at how they look: they look both the same at 1.29 and 1.49, both with a blue end at the bottom one and a purple end at the top one ..
You see?
I think this is not right, because in the first type of junction/splitting (1.29) you should have a same color "end" , because the exchanged DNA is in the middle , not at the end..
Not sure this is the mistake your teacher is looking for!
ANyway: let us know what the mistake is , because I would like to know because I can not figure it out (besides what I explained here)!
or the double centromeres in the film? not sure how they are seen or drawn today but I learnt that there's only one per chromosome as in the image above..
I think you might be right, pito, thanks. I'm awaiting my teacher's feedback, will post when I get it.
hobgoblin, it could be that as well, but I think she meant something wrong that relates more to the process of recombination, after all, that's why she showed us the video.
double centromeres? Nha, I think its just 1 centrome, but drawn a bit strange.
hobglobin on Mon Dec 2 15:50:38 2013 said:
or the double centromeres in the film? not sure how they are seen or drawn today but I learnt that there's only one per chromosome as in the image above..
So this is the answer: the ends of the chromatids after the first recombination should not be coloured differently (purple on blue chromosome, blue on purple chromosome), rather, only a short region should be coloured differently. It is called "gene conversion" and does not include "crossing-over", which doesn't happen until later in the video.